Atypical Parkinsonism, also known as “Parkinson’s Plus,” encompasses conditions resembling Parkinson’s disease but with additional symptoms and faster progression. Diagnosis relies on medical history and examination, lacking definitive blood or imaging tests. While resembling Parkinson’s, they often have distinctive features, leading to potential misdiagnosis. Treatments focus on symptom management, as there are currently no therapies to halt or slow disease progression.

Dementia with Lewy bodies (DLB) presents movement issues alongside significant cognitive impairment, often preceding or coinciding with Parkinsonism. Conversely, Multiple System Atrophy (MSA) impacts autonomic functions and movement, while Corticobasal Degeneration (CBD) and Progressive Supranuclear Palsy (PSP) involve cognitive, behavioral, and motor symptoms. Despite shared protein accumulations and symptoms, these conditions necessitate tailored treatments. Research efforts aim to understand their etiology better, develop diagnostic tools, and explore therapeutic targets, holding promise for improved management and potential disease-modifying treatments.

Reference: Atypical Parkinsonism. The Michael J. Fox Foundation for Parkinson’s Research. Accessed April 25, 2024. https://www.michaeljfox.org/news/atypical-parkinsonism