Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disease characterized by diverse symptoms, often leading to initial misdiagnosis as idiopathic Parkinson’s disease. Diagnosis relies heavily on clinical features, particularly autonomic dysfunction like orthostatic hypotension. Management aims at symptom relief through both pharmacologic therapies for movement disorders and orthostatic hypotension, alongside nonpharmacologic interventions such as dietary adjustments and therapies like physical and speech therapy.

MSA carries a grim prognosis, with rapid progression and a median survival of 6.2 to 9.5 years. Despite ongoing research, there is currently no cure for the disease. Treatment focuses on enhancing quality of life and managing symptoms, often necessitating a multidisciplinary approach involving various therapists. Alongside pharmacologic treatments, nonpharmacologic interventions like dietary modifications and tailored therapies play a crucial role in comprehensive management.

Reference: Diedrich A. Multiple System Atrophy Treatment & Management. Medscape. Updated October 26, 2022. Accessed April 25, 2024. https://emedicine.medscape.com/article/1154583-treatment